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您当前的位置：首页 » 公司动态 » Takasago BINAP 配体及钌类催化剂在不对称氢化反应中的应用
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Takasago BINAP 配体及钌类催化剂在不对称氢化反应中的应用
发布时间：2013-04-15        浏览次数：465        返回列表

BINAP由于空间位阻大、双萘环的消旋障碍高，限制了连接两萘环的化学键自由旋转，可与钌、铑和钯配合物催化剂协同进行对映选择性反应。BINAP金属配合物催化剂在烯烃、酮、亚胺的不对称氢化、关环以及C-C键形成等反应中应用广泛。BINAP配体及BINAP Ru Cymene催化剂、BINAP Ru Dimer催化剂、BINAP Ru Acetate催化剂和BINAP Ru Diammine 催化剂，催化活性高（TOF可达30,000以上），对映选择性好（ee＞95%，收率可达99%），供货稳定，并可提供公斤级大包装定制，可满足科研和生产的不同需求。

BINAP 配体

Technical Notes:
1. Ligand (BINAP) employed in the rhodium-catalyzed asymmetric 1,4-addition of arylalanes on trisubstituted enones.
2. Ligand (TolBINAP) used in the copper-catalyzed asymmetric synthesis of cyclopropanes via tandem conjugate addition and intramolecular enolate trapping.
3. Ligand (XylBINAP) used in the asymmetric reduction of ketone via ruthenium-catalyzed transfer hydrogenation.
4. Ligand (H8-BINAP) for palladium-catalyzed enantioselective hydrogenation of substituted indoles.

References:
1. Angew. Chem. Int. Ed., 2010, 49, 7769.
2. J. Am. Chem. Soc., 2010, 132, 14349.
3. J. Am. Chem. Soc., 2011, 133, 10696.
4. J. Am. Chem. Soc., 2010, 132, 8909.

96-6950 Takasago BINAP Ligand Kit

15-0150

(R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl, 98%

(R)-(+)-BINAP [76189-55-4]

15-0152

(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl, 98%

(R)-(+)-TolBINAP[99646-28-3]

15-0476

(R)-(+)-2,2'-Bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl, 98%

(R)-(+)-XylBINAP[137219-86-4]

15-0151

(S)-(-)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl, 97%

(S)-(-)-BINAP[76189-56-5]

15-0153

(S)-(-)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl, 98%

(S)-(-)-TolBINAP[100165-88-6]

15-0477

(S)-(-)-2,2'-Bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl, 98% (S)-(-)-XylBINAP

[135139-00-3]

BINAP 钌类催化剂

Technical Note:
1. This catalyst has shown to effect the highly enantioselective hydrogenation of functionalized ketones where the substituents
are dialkylamino, hydoxy, siloxy, carbonyl, ester, amide or thioester.
2. The ruthenium catalyzed hydrogenation of aryl propenoic acid to produce the drug Ibuprofen.
3. Catalyst system that exhibits high catalytic activity and enantioselectivity in the hydrogenation of enamines.

References:
1. Tetrahedron Lett., 2008, 49, 4836.
2. J. Org. Chem., 1996, 61, 5510.
3. Topics Organometal. Chem. 2004, 6, 63
4. J. Org. Chem., 1994, 59, 297.

96-6951 Takasago BINAP Ru Cymene Catalyst Kit

44-0084

Chloro[(R)-(+)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl](p-cymene) ruthenium(II) chloride

[RuCl(p-cymene)((R)-binap)]Cl[145926-28-9]

44-0088

Chloro[(R)-(+)-2,2'-bis(di-p-tolyl-phosphino)-1,1'-binaphthyl](p-cymene) ruthenium(II) chloride

[RuCl(p-cymene) ((R)-tolbinap)]Cl [131614-43-2]

44-0092

Chloro{(R)-(+)-2,2'-Bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride

[RuCl(p-cymene)((R)-xylbinap)]Cl[944451-24-5]

44-0086

Chloro[(S)-(-)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl](p-cymene) ruthenium(II) chloride

[RuCl(p-cymene) ((S)-binap)]Cl [130004-33-0]

44-0089

Chloro[(S)-(-)-2,2'-bis(di-p-tolylphosphino)-1,1'-binaphthyl](p-cymene)ruthenium(II) chloride

[RuCl(p-cymene)((S)-tolbinap)]Cl [228120-95-4]

44-0093

Chloro{(S)-(-)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride

[RuCl(p-cymene) ((S)-xylbinap)]Cl [944451-25-6]

96-6952 Takasago BINAP Ru Dimer Catalyst Kit

44-0510

 Dimethylammonium dichlorotri(μ-chloro)bis[(R)-(+)-2,2'-bis (diphenylphosphino)-1,1'-binaphthyl]diruthenate(II)

[NH2Me2][{RuCl((R)-binap)}2(μ-Cl)3][199684-47-4]

44-0512

Dimethylammonium dichlorotri(μ-chloro)bis[(R)-(+)-2,2'-bis (di-ptolylphosphino)-1,1'-binaphthyl]diruthenate(II)

[NH2Me2][{RuCl((R)-tolbinap)}2(μ-Cl)3][749935-02-2]

44-0514

Dimethylammonium dichlorotri(μ-chloro)bis{(R)-(+)-2,2'-bis [di(3,5-xylyl)phosphino]-1,1'-binaphthyl}diruthenate(II)

[NH2Me2][{RuCl((R)-xylbinap)}2(μ-Cl)3][944451-08-5]

44-0511

Dimethylammonium dichlorotri(μ-chloro)bis[(S)-(-)-2,2'-bis (diphenylphosphino)-1,1'-binaphthyl]diruthenate(II)

[NH2Me2][{RuCl((S)-binap)}2(μ-Cl)3][199541-17-8]

44-0513

 Dimethylammonium dichlorotri(μ-chloro)bis[(S)-(-)-2,2'-bis (di-ptolylphosphino)-1,1'-binaphthyl]diruthenate(II)

[NH2Me2][{RuCl((S)-tolbinap)}2(μ-Cl)3][309735-86-2]

44-0515

 Dimethylammonium dichlorotri(μ-chloro)bis{(S)-(-)-2,2'-bis [di(3,5-xylyl)phosphino]-1,1'-binaphthyl}diruthenate(II)

[NH2Me2][{RuCl((S)-xylbinap)}2(μ-Cl)3][944451-10-9]

96-6953 Takasago BINAP Ru Acetate Catalyst Kit

96-6954 Takasago BINAP Ru Diammine Catalyst Kit

注：1、以上产品均为Takasago®产品；
      2、可提供大包装定制服务。