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您当前的位置：首页 » 公司动态 » Takasago SEGPHOS 配体及钌类催化剂在不对称氢化反应中的应用
公司动态
Takasago SEGPHOS 配体及钌类催化剂在不对称氢化反应中的应用
发布时间：2013-04-16        浏览次数：1052        返回列表

SEGPHOS®是继BINAP之后发现的一种应用于不对称反应中的手性配体，它的芳香环之间具有较狭窄的二面角，因此SEGPHOS®能增加金属配合物的对映选择性与活性。百灵威提供STREM品牌SEGPHOS®配体及钌催化剂，适用底物广、催化活性高（TOF可达30,000以上，用量少、成本低）、对映选择性好（ee＞95%，纯化更简单）、收率高（可达99%），供货稳定，可有效帮助您加快科研进程。

SEGPHOS® 配体

Technical Notes:
1. Iridium-catalyzed asymmetric hydrogenation of quinolines activated by chloroformates.
2. Diastereo- and enantioselective ruthenium-catalyzed hydrohydroxyalkylation of 2-silyl-butadienes.
3. Asymmetric Ag-catalyzed cycloadditions.

References:
1. Angew. Chem. Int. Ed., 2006, 45, 2260.
2. J. Am. Chem. Soc., 2011, 133, 10582.
3. J. Org. Chem., 2011, 76, 1945.

96-6900 Takasago SEGPHOS® Ligand Kit

15-0136

(R)-(+)-5,5'-Bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole, min. 98%

(R)-(+)-SEGPHOS®[244261-66-3]

15-0137

(S)-(-)-5,5'-Bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole, min. 98%

(S)-(-)-SEGPHOS®[210169-54-3]

15-0478

(R)-(+)-5,5'-Bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98%

(R)-(+)-DM-SEGPHOS®[850253-53-1]

15-0479

(S)-(-)-5,5'-Bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98%

(S)-(-)-DM-SEGPHOS®[210169-57-6]

15-0066

(R)-(-)-5,5'-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98%

(R) -(-)-DTBM- SEGPHOS® [566940-03-2]

15-0067

(S)-(+)-5,5'-Bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole, min. 98%

(S)-(+)-DTBM- SEGPHOS® [210169-40-7]

SEGPHOS® 钌类催化剂

Technical Notes:
1. Highly active highly enantioselective catalyst for hydrogenation of functionalized ketones. Slightly higher temperature is necessary to activate the cymene complexes. Asymmetric hydrogenation of α-substituted-β-alkyl-β-ketoesters accompanied by dynamic kinetic resolution.
2. Highly enantioselective, highly active catalyst for hydrogenation of functionalized ketones. The chlororuthenate salts show catalytic activity at relatively low temperature.
3. Biaryl bisphosphine ligand with narrow dihedral angle. The DM-SEGPHOS ligand, as the ruthenium complex, gives superior enantioselectivity and diastereoselectivity in the asymmetric hydrogenation of α-substituted-β-ketoesters. Ruthenium catalyzed enantioselective synthesis of β amino acids by hydrogenation.

Reference:
1. U.S. Pat. 7038087.
2. Adv. Synth. Catal., 2001, 343, 264.
3. WIPO Pat. WO2005028419.+

Takasago SEGPHOS® Ru Cymene Catalysts

44-0096

Chloro[(R)-(+)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole](p-cymene)ruthenium(II)chloride[RuCl(p-cymene)

((R)-segphos®)]Cl [944451-28-9]

44-0097

Chloro[(S)-(-)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole](p-cymene)ruthenium(II)chloride[RuCl(p-cymene)

((S)-segphos®)]Cl [944451-29-0]

44-0098

Chloro{(R)-(+)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}(p-cymene)ruthenium(II)chloride[RuCl(p-cymene)

((R)-dm- segphos®)]Cl [944451-30-3]

44-0099

Chloro{(S)-(-)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}(p-cymene)ruthenium(II)chloride[RuCl(p-cymene)

((S)-dm- segphos®)]Cl [944451-31-4]

44-0102

Chloro{(R)-(-)-5,5'-bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole}(p-cymene)ruthenium(II) chloride

[RuCl(p-cymene)((R)-dtbm- segphos®)]Cl [944451-32-5]

44-0103

Chloro{(S)-(+)-5,5'-bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole}(p-cymene)ruthenium(II) chloride

[RuCl(p-cymene)((S)-dtbmsegphos®)]Cl [944451-33-6]

Takasago SEGPHOS® Ru Dimer Catalysts

44-0518

Dimethylammoniumdichlorotri(μ-chloro)bis[(R)-(+)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole]diruthenate(II)

[NH2Me2][{RuCl((R)-segphos®)}2(μ-Cl)3][346457-41-8]

44-0519

Dimethylammoniumdichlorotri(μ-chloro)bis[(S)-(-)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole]diruthenate(II)

[NH2Me2][{RuCl((S)-segphos®)}2(μ-Cl)3][488809-34-3]

44-0520

Dimethylammoniumdichlorotri(μ-chloro)bis{(R)-(+)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}diruthenate(II)

[NH2Me2][{RuCl((R)-dm-segphos®)}2(μ-Cl)3] [935449-46-0]

44-0521

Dimethylammoniumdichlorotri(μ-chloro)bis{(S)-(-)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzdioxole}diruthenate(II)

[NH2Me2][{RuCl((S)-dm-segphos®)}2(μ-Cl)3] [944451-14-3]

Takasago SEGPHOS® Ru Acetate Catalysts

44-0168

Ru(OAc)2[(R)-segphos®][944450-48-0]

44-0169

Ru(OAc)2[(S)-segphos®][373650-12-5]

44-0174

Ru(OAc)2[(R)-dm-segphos®][944450-49-1]

44-0176

Ru(OAc)2[(S)-dm-segphos®][944450-50-4]

Takasago SEGPHOS® Ru Diammine Catalysts

44-0214

RuCl2[(R)-dm-segphos®][(R)-daipen][944450-43-5]

44-0215

RuCl2[(S)-dm-segphos®][(S)-daipen][944450-44-6]

44-0228

RuCl2[(R)-dm-segphos®][(R,R)-dpen] [944450-45-7]

44-0229

RuCl2[(S)-dm-segphos®][(S,S)-dpen] [944450-46-8]

注：1、以上产品均为Takasago®产品；
       2、可提供大包装定制服务。